What do you typically use your computer for? That’s going to have a major impact. If it’s pretty basic stuff (web browsing, text editing, etc) you shouldn’t have any issue. If it’s something that’s more complicated or unusual, then sometimes it’s easy to do and sometimes not, depending on what you want to do. In general, a little bit of comfort searching the web and working in the command line helps a lot with troubleshooting Linux
I do a lot of data analysis and visualization in my job, and you are correct. I use Excel when I need to share data with co-workers, but I prefer to use Python for just about everything else. I see no reason to embed Python in Excel.